281-sample scRNA-seq
Single-cell RNA sequencing
12 cell-type viewsExplore
Yulab
Towards molecular precision in cold-region cardiovascular medicine through intravascular imaging and multimodal data
This portal allows users to explore blood atlas data from a coronary artery disease cohort.
MOOP-CAD · Multi-omics & coronary OCT imaging
Coronary Artery Disease Blood Atlas: Multi-Omics and Coronary OCT Imaging
A multi-omics blood atlas incorporating coronary optical coherence tomography (OCT) imaging
01 / THE STUDY
Overview
MOOP (Multi-omics Analysis of OCT-diagnosed Plaque Subsets in Coronary Artery Disease) is a multi-omic blood resource that characterizes the genomic, cellular, and molecular landscape of coronary artery disease (CAD) across its clinical spectrum. Integrating genomic variation, single-cell transcriptomic and surface-protein data, and circulating proteomic and metabolomic profiles, it captures blood cell heterogeneity and CAD-associated molecular alterations.
Distinctively, MOOP incorporates coronary optical coherence tomography (OCT) for high-resolution plaque characterization and, together with detailed clinical phenotyping, provides a framework for relating molecular patterns to OCT-defined plaque features.
Spanning healthy individuals, chronic coronary syndrome, acute coronary syndrome, and post-ACS, MOOP supports the exploration of CAD heterogeneity and informs data-driven discovery in cardiovascular research.
02 / INTERACTIVE DATA
Explore the datasets
Explore single-cell RNA expression, untargeted metabolomics and Olink protein profiling in the MOOP cohort.
274-sample metabolome
Comprehensive untargeted metabolome
11 metabolite categories
- GP
- Amino acids and their metabolites
- GL
- Organic acids and their derivatives
- Benzene and substituted derivatives
- FA
- SP
- Heterocyclic compounds
- Aldehydes, ketones, esters
- Nucleotides and their metabolites
- Carbohydrates and their metabolites
Interactive access coming soon.
384-plex inflammation panel
Olink protein profiling
Analysis views
- Overview of protein expression in the MOOP cohort
- Differential analysis
Interactive access coming soon.
03 / ABOUT
About us
Our research centers on the molecular basis of cardiovascular events in cold regions.
Using intravascular imaging together with multimodal data — multi-omic profiles, cardiac imaging, and longitudinal clinical records — we investigate how cold exposure reshapes plaque biology and myocardial injury, uncover the regulatory networks and circulating signatures that define cold-sensitive phenotypes, and translate these findings into imaging-guided strategies for early risk stratification and targeted therapy.
04 / CORRESPONDENCE
Contact the research team
Yulab · MOOP-CAD research teamCorresponding author, institution and contact details
will be added after confirmation.